Kifunensine, mannosidase inhibitor

Code: K1140-1MG D2-231

Application

Kifunensine has been used as an inhibitor of mannosidase I in Jurkat T-cells, human embryonic kidney (HEK293T/17) cells and in mouse embryonic fibroblast cells.

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Application

Kifunensine has been used as an inhibitor of mannosidase I in Jurkat T-cells, human embryonic kidney (HEK293T/17) cells and in mouse embryonic fibroblast cells.

Biochem/physiol Actions

Kifunensine suppresses endoplasmic reticulum-associated degradation (ERAD) via the inhibition of endoplasmic reticulum-associated mannosidase activity. It is also a glycosidase inhibitor for Class I CAZy glycosylhydrolase family 47.

Kifunensine is a selective inhibitor of class I glycoprotein-processing α-mannosidases.

General description

Kifunensine is an alkaloid compound, isolated from the actinomycete Kitasporia kifunensis.

assay≥98%
biological sourcesynthetic (organic)
formfilm or powder, solid
Gene Informationhuman ... MAN1A1(4121), MAN1A2(10905), MAN1B1(11253), MAN1C1(57134)mouse ... MAN1A1(17155), MAN1A2(17156), MAN1B1(227619), MAN1C1(230815)rat ... MAN1A1(294410), MAN1A2(295319), MAN1B1(499751), MAN1C1(362625)
InChI keyOIURYJWYVIAOCW-PQMKYFCFSA-N
InChI1S/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1
Quality Level100
solubilitywater, double-distilled: 50 mM
storage temp.−20°C
Cas Number109944-15-2
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